Nanoparticle-mediated gene delivery, genomic editing and ligand-targeted modification in various cell populations
作者： Vaibhav A. Pandit , Shiva Prasad Kotha , Andre Ronald Watson
DOI:
关键词: Polynucleotide 、 Polymer 、 Ligand 、 Cationic polymerization 、 Gene delivery 、 Materials science 、 Combinatorial chemistry 、 Polymer chemistry 、 Anionic addition polymerization 、 Nanoparticle 、 Cell
摘要: An improved nanoparticle for transfecting cells is provided. The includes a core polyplex and silica coating on the and, optionally, polymer attached to an outer surface of coating, where anionic polymer, cationic polypeptide, polynucleotide. Also provided method modifying intracellular polynucleotides. contacting cell with that
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