作者: Krisztina Krempels , Robert C. Tuttle , Tenshuk A. Kadima , Lajos Hegedus , Howard A. Kaplan
DOI:
关键词: Paclitaxel 、 Organic solvent 、 Chromatography 、 Materials science 、 Serum albumin 、 Albumin 、 Aqueous solution 、 Composition (visual arts)
摘要: An optically clear, pharmaceutically acceptable aqueous composition comprising paclitaxel or a derivative thereof, serum albumin and vehicle, wherein the comprises no more than 10 % organic solvent has pH of about 3.0 to 4.8, is described. The can be fatted defatted, optionally lyophilized reconstituted. At least 70 bound albumin, ratio at 1:5, concentration 25 νg/ml. Methods making using this are also provided.