Thoracic aortic aneurysm: unlocking the “silent killer” secrets

摘要: Thoracic aortic aneurysm (TAA) is an increasingly recognized condition that often diagnosed incidentally. This review discusses ten of the most relevant epidemiological and clinical secrets this disease; (1) difference in pathogenesis between ascending descending TAAs. TAAs at these two sites act as different diseases, which related to embryologic origins aorta. (2) The familial pattern genetics thoracic aneurysms. Syndromic only explain 5% inheritance. (3) effect female sex on TAA growth outcome. Females have been found worse outcomes compared males. (4) Guilt by Association. are associated with abdominal aneurysms, intracranial bicuspid valve, inflammatory disorders. (5) Natural history Important findings made regarding expansion rate (in relation pattern, location size), also risk rupture or dissection. (6) size paradox. Size not a sufficient predictor (7) Biomarker void. Although many serum biomarkers studied, imaging remains reliable method for diagnosis follow-up. (8) Indications repair. Decisions depending symptoms, location, size, patterns. (9) Types Both open endovascular repair options available certain (10) Medical treatment. efficacy prescribing beta blockers, angiotensin converting enzyme inhibitors receptor blockers dubious.