Establishment of a Genetically Confirmed Breeding Colony of Mastomys natalensis from Wild-Caught Founders from West Africa.

摘要: Mastomys natalensis are a ubiquitous and often dominant rodent across sub-Saharan Africa. Importantly, they natural reservoir for microbial pathogens including Lassa virus (LASV), the etiological agent of fever in humans. Lassa-infected rodents have been documented West Africa coincide with regions where annual outbreaks occur. Zoonotic transmission to humans most occurs directly from infected rodents. Little is known about LASV infection kinetics transmissibility M.natalensis, primarily due available animals. Here, we describe establishment laboratory breeding colony genetically confirmed M.natalensis wild-captured This will provide convenient source animals study other emerging that utilize M. their enzootic lifecycles.