Xanthoceraside rescues learning and memory deficits through attenuating beta-amyloid deposition and tau hyperphosphorylation in APP mice
作者： Ge Jin , Li-Hua Wang , Xue-Fei Ji , Tian-Yan Chi , Yue Qi
DOI: 10.1016/J.NEULET.2014.04.032
关键词: Beta (finance) 、 Endocrinology 、 Internal medicine 、 Blot 、 Amyloid precursor protein 、 Xanthoceraside 、 Neuroscience 、 Hippocampus 、 Amyloid deposition 、 Genetically modified mouse 、 Phosphorylation 、 Chemistry
摘要: Xanthoceraside, a triterpenoid saponin, has been shown to reverse cognitive deficits in several Alzheimer's disease (AD) animal models. However, the effects of xanthoceraside on Aβ deposition pathology and APP processing AD are unclear. Here, we show that at doses 0.08 0.32 mg/kg/d for 6 months significantly improved learning memory impairment transgenic mice assessed by Y maze novel object recognition tests. Immunohistochemical analyses revealed strongly attenuated β-amyloid brains mice. Western blotting decreased tau phosphorylation protein levels Ser396 Ser404 hippocampus; also GSK-3β phosphorylation. These results suggest could be promising candidate therapy AD.
sci-hub.se 参考文章(28)
J.C Richardson, David R. Howlett, The pathology of APP transgenic mice: a model of Alzheimer's disease or simply overexpression of APP? Histology and Histopathology. ,vol. 24, pp. 83- 100 ,(2009) , 10.14670/HH-24.83
Akihiko Takashima, Amyloid-β, Tau, and Dementia Journal of Alzheimer's Disease. ,vol. 17, pp. 729- 736 ,(2009) , 10.3233/JAD-2009-1090
Shi Jie Liu, Ai Hong Zhang, Hong Lian Li, Qun Wang, Heng Mei Deng, William J Netzer, Huaxi Xu, Jian Zhi Wang, None, Overactivation of glycogen synthase kinase-3 by inhibition of phosphoinositol-3 kinase and protein kinase C leads to hyperphosphorylation of tau and impairment of spatial memory. Journal of Neurochemistry. ,vol. 87, pp. 1333- 1344 ,(2003) , 10.1046/J.1471-4159.2003.02070.X
Paul F Chapman, Gail L White, Matthew W Jones, Deirdre Cooper-Blacketer, Vanessa J Marshall, Michael Irizarry, Linda Younkin, Mark A Good, TVP Bliss, Bradley T Hyman, Steven G Younkin, Karen K Hsiao, None, Impaired synaptic plasticity and learning in aged amyloid precursor protein transgenic mice Nature Neuroscience. ,vol. 2, pp. 271- 276 ,(1999) , 10.1038/6374
Masatake Fujimura, Fusako Usuki, Masumi Sawada, Akihiko Takashima, Methylmercury induces neuropathological changes with tau hyperphosphorylation mainly through the activation of the c-jun-N-terminal kinase pathway in the cerebral cortex, but not in the hippocampus of the mouse brain NeuroToxicology. ,vol. 30, pp. 1000- 1007 ,(2009) , 10.1016/J.NEURO.2009.08.001
Haythum O. Tayeb, Hyun Duk Yang, Bruce H. Price, Frank I. Tarazi, Pharmacotherapies for Alzheimer's disease: Beyond cholinesterase inhibitors Pharmacology & Therapeutics. ,vol. 134, pp. 8- 25 ,(2012) , 10.1016/J.PHARMTHERA.2011.12.002
Tian-Yan Chi, Li-Hua Wang, Chan Qu, Bai-Zhen Yang, Xue-Fei Ji, Yi Wang, Toru Okuyama, Okada Yoshihito, Li-Bo Zou, Protective effects of xanthoceraside on learning and memory impairment induced by Aβ25–35 in mice Journal of Asian Natural Products Research. ,vol. 11, pp. 1019- 1027 ,(2009) , 10.1080/10286020903337832
Mirsada Čaušević, Umbreen Farooq, Simon Lovestone, Richard Killick, β-Amyloid precursor protein and tau protein levels are differently regulated in human cerebellum compared to brain regions vulnerable to Alzheimer's type neurodegeneration. Neuroscience Letters. ,vol. 485, pp. 162- 166 ,(2010) , 10.1016/J.NEULET.2010.08.088
Tin-Tin Win-Shwe, Hidekazu Fujimaki, Yuji Fujitani, Seishiro Hirano, Novel object recognition ability in female mice following exposure to nanoparticle-rich diesel exhaust. Toxicology and Applied Pharmacology. ,vol. 262, pp. 355- 362 ,(2012) , 10.1016/J.TAAP.2012.05.015
Yun Ding, Aimin Qiao, Guo-Huang Fan, Indirubin-3'-monoxime rescues spatial memory deficits and attenuates beta-amyloid-associated neuropathology in a mouse model of Alzheimer's disease. Neurobiology of Disease. ,vol. 39, pp. 156- 168 ,(2010) , 10.1016/J.NBD.2010.03.022