Paclitaxel in doxorubicin-refractory or mitoxantrone-refractory breast cancer: a phase I/II trial of 96-hour infusion.
作者： W H Wilson , S L Berg , G Bryant , R E Wittes , S Bates
DOI: 10.1200/JCO.1994.12.8.1621
关键词: Oncology 、 Breast cancer 、 Paclitaxel 、 Mucositis 、 Metastatic breast cancer 、 Phases of clinical research 、 Mitoxantrone 、 Doxorubicin 、 Internal medicine 、 Pharmacokinetics 、 Medicine
摘要: PURPOSEA phase I study of paclitaxel infused over 96-hours was performed to determine toxicity, maximum-tolerated dose (MTD), and pharmacokinetics in patients with incurable lymphomas solid tumors. A II at the MTD doxorubicin/mitoxantrone-refractory metastatic breast cancer.PATIENTS AND METHODSIn study, levels ranged from 120 160 mg/m2, administered on a 21-day cycle. Patients cancer who had either no response or partial (PR) doxorubicin mitoxantrone measurable disease were eligible for studies. Expression multidrug resistance (mdr-1) gene determined tumor biopsies by mRNA quantitative polymerase chain reaction.RESULTSTwelve received total 73 cycles study. Dose-limiting mucositis and/or grade IV granulocytopenia reached 140 mg/m2 selected as dose. Thirty-...
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