Helminth Electron Transport Inhibitors Produced by Fungi

作者: Rokuro Masuma , Kazuro Shiomi , Satoshi Ōmura

DOI: 10.1007/978-3-642-00286-1_12

关键词: Electron transport chainOxidative phosphorylationVerticipyroneHelminthsBiochemistryChemistryEchinococcus multilocularisAnthelminticAnimal healthReductase

摘要: The electron transport chain is linked with oxidative phosphorylation to produce ATP effectively. Some inhibitors have been obtained from fungi and are being used as anti-infectives in human animal health agriculture. also very useful tools helping elucidate the mechanisms of chain. NADH-fumarate reductase a part anaerobic system found many helminth parasites. Nafuredin, verticipyrone some other new compounds isolated fungal culture broths inhibitors, them their derivatives show promising anthelmintic activity.

参考文章(155)
M.D. Esposti, A. Ghelli, M. Crimi, E. Estornell, R. Fato, G. Lenaz, Complex I and complex III of mitochondria have common inhibitors acting as ubiquinone antagonists. Biochemical and Biophysical Research Communications. ,vol. 190, pp. 1090- 1096 ,(1993) , 10.1006/BBRC.1993.1161
Hideaki Ui, Kazuro Shiomi, Hideaki Suzuki, Hiroko Hatano, Hiromi Morimoto, Yuichi Yamaguchi, Rokuro Masuma, Toshiaki Sunazuka, Hiroyuki Shimamura, Kimitoshi Sakamoto, Kiyoshi Kita, Hideto Miyoshi, Hiroshi Tomoda, Satoshi Ōmura, Verticipyrone, a new NADH-fumarate reductase inhibitor, produced by Verticillium sp. FKI-1083. The Journal of Antibiotics. ,vol. 59, pp. 785- 790 ,(2006) , 10.1038/JA.2006.103
S. Omura, H. Miyadera, H. Ui, K. Shiomi, Y. Yamaguchi, R. Masuma, T. Nagamitsu, D. Takano, T. Sunazuka, A. Harder, H. Kolbl, M. Namikoshi, H. Miyoshi, K. Sakamoto, K. Kita, An anthelmintic compound, nafuredin, shows selective inhibition of complex I in helminth mitochondria Proceedings of the National Academy of Sciences of the United States of America. ,vol. 98, pp. 60- 62 ,(2001) , 10.1073/PNAS.98.1.60
Georg Groth, Structure of spinach chloroplast F1-ATPase complexed with the phytopathogenic inhibitor tentoxin. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 99, pp. 3464- 3468 ,(2002) , 10.1073/PNAS.052546099
TADASHI ARAI, YUZURU MIKAMI, KAZUTAKA FUKUSHIMA, TAKEHIKO UTSUMI, KATSUKIYO YAZAWA, A new antibiotic, leucinostatin, derived from Penicillium lilacinum. The Journal of Antibiotics. ,vol. 26, pp. 157- 161 ,(1973) , 10.7164/ANTIBIOTICS.26.157
Julia M. Dickinson, James R. Hanson, Peter B. Hitchcock, Norman Claydon, Structure and biosynthesis of harzianopyridone, an antifungal metabolite of Trichoderma harzianum Journal of The Chemical Society-perkin Transactions 1. pp. 1885- 1887 ,(1989) , 10.1039/P19890001885
Alexey G. Kruglov, Maria A. Andersson, Raimo Mikkola, Merja Roivainen, Laszlo Kredics, Nils-Erik L. Saris, Mirja S. Salkinoja-Salonen, Novel Mycotoxin from Acremonium exuviarum Is a Powerful Inhibitor of the Mitochondrial Respiratory Chain Complex III Chemical Research in Toxicology. ,vol. 22, pp. 565- 573 ,(2009) , 10.1021/TX800317Z
Adebowale Adebiyi, Elizabeth M. McNally, Jonathan H. Jaggar, Sulfonylurea receptor-dependent and -independent pathways mediate vasodilation induced by ATP-sensitive K+ channel openers. Molecular Pharmacology. ,vol. 74, pp. 736- 743 ,(2008) , 10.1124/MOL.108.048165
K. Ohtani, H. Yamamoto, K. Akimitsu, Sensitivity to Alternaria alternata toxin in citrus because of altered mitochondrial RNA processing. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 99, pp. 2439- 2444 ,(2002) , 10.1073/PNAS.042448499
Fei Wang, Du-Qiang Luo, Ji-Kai Liu, Aurovertin E, a New Polyene Pyrone from the Basidiomycete Albatrellus confluens The Journal of Antibiotics. ,vol. 58, pp. 412- 415 ,(2005) , 10.1038/JA.2005.53