Immunoendocrinology: faulty hormonal imprinting in the immune system.

摘要: Hormonal imprinting is an epigenetic process which taking place perinatally at the first encounter between developing hormone receptors and their target hormones. The hormonal influences binding capacity of receptors, synthesis cells, other hormonally regulated functions, as sexual behavior, aggressivity, empathy, etc. However, during critical period, when window for open, molecules similar to physiological imprinters synthetic analogs, members families, environmental pollutants, can cause faulty with life-long consequences. immune system, cells also have hormones, very sensitive imprinting, causes alterations in antibody cytokine production, ratio defense against bacterial viral infections well malignant tumors. Immune (lymphocytes, monocytes, granulocytes mast cells) are producing hormones secreted into blood circulation transported locally (packed transport). This disturbed by imprinting. As differentiating whole life, could develop any time, however, most decisive perinatal inherited progenies general especially case system. In our modern world number amount artificial (e.g. endocrine disruptors drugs) enormously increasing. effects dangerous system shown paper. present future consequences flood imprintings unpredictable it discussed.