Knockout Models of the Renin-Angiotensin System

摘要: Angiotensin II, generated from its precursor angiotensinogen by renin and angiotensin-converting enzyme (ACE), mediates biological effects via two different classes of G protein-coupled receptors, termed angiotensin II AT1 receptors AT2 receptors. Transgenic mouse models have greatly advanced our understanding the specific functions individual parts aldosterone system (RAAS). Recently, all components RAAS been deleted homologous recombination in genome. This review summarizes vivo significance available knockout lines RAAS. While most classical are mediated receptor, recent evidence suggests that may antagonize cardiovascular receptor activation. Most importantly, required to inhibit growth-promoting vascular smooth muscle cells cardiac myocytes. Targeted deletions ACE genes extended knowledge embryonic system. recently, a novel angiotensin-converting-enzyme (ACE2) has cloned mice. Thus, experimental findings transgenic animal offer new insights into physiological regulation help development therapeutical strategies for treating human diseases.