S6 Phosphorylation and the p70s6k/p85s6k
作者： Stefano Ferrari , George Thomas
DOI: 10.3109/10409239409083485
关键词: c-Raf 、 Casein kinase 2 、 MAP2K7 、 Serine/threonine-specific protein kinase 、 Cell biology 、 Biochemistry 、 ASK1 、 Akt/PKB signaling pathway 、 MAP kinase kinase kinase 、 Biology 、 Cyclin-dependent kinase 2 、 Molecular biology
摘要: AbstractActivation of cell growth leads to the multiple phosphorylation 40S ribosomal protein S6. The kinase responsible for controling this event is termed p70s6k/p85s6k. Both isoforms are derived from a common gene activated by complex set events; each resides in unique cellular compartment: p70s6kin cytoplasm and p85s6kin nucleus. Although p70s6k/p85s6krepresent first mitogen-activated serine/threonine described, signaling pathway leading activation both remains obscure. Recent studies have shown that distinct p21rasand p42mapk/p44mapk, bifurcation these pathways takes place at level receptor. Experiments with point mutants PDGF receptor inhibitors phosphatidyl-inositol-3-OH implicated latter molecule event, but more recent findings suggest an alternative route may be employed. p70s6ksignaling can also b...
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