Effects of dexamethasone on tumor-induced brain edema and its distribution in the brain of monkeys

摘要: ✓ A human choriocarcinoma was successfully adapted to grow in the brain of monkeys (Macaca mulatta), thus providing a model tumor-induced edema. Four animals were given dexamethasone (3 mg/kg/day) during 3 5 days after onset clinical signs, and other five received no treatment for same period. Tissue water electrolyte content treated untreated compared cortex white matter at various distances from edge tumor. In animals, 67.9% 23.6% swelling detected adjacent remote matter, respectively, but only 11.8% noted cortex. with these percentages improved 32.4% 11.9% corresponding 4.9% The changes shown edematous control also demonstrated significant improvement dexamethasone-treated group. radioactivity 3H-dexamethasone 60 minutes afte...