Metachronous hepatic metastases from gastric carcinoma: a multicentric survey.

作者: G.A.M. Tiberio , A. Coniglio , A. Marchet , D. Marrelli , S. Giacopuzzi

DOI: 10.1016/J.EJSO.2008.12.017

关键词: Chart reviewCancerDiseaseTherapeutic approachGastric carcinomaOncologyClinical significanceGastrectomyInternal medicineMedicineChemotherapy

摘要: Abstract Background The treatment of hepatic metastases from gastric cancer is controversial, due to biologic aggressiveness the disease. Objective To survey clinical approach subset patients presenting with metachronous as sole site recurrence after curative resection cancer, focusing on results achieved by different therapies and investigate prognostic factors major relevance. Methods Retrospective multi-center chart review evaluating 73 patients, previously submitted D  ≥ 2 gastrectomy for who developed exclusive recurrence. Prognostic related patient, malignancy its treatment, metastatic disease therapy were evaluated. Results Forty-five received supportive care, 17 chemotherapy, 11 resection. Survival was independently influenced variables T ( p  = 0.019), N  = 0.05) G  = 0.018) primary therapeutic  = 0.08) 80.8%, 30.3% 20.2% surgical Conclusions Our data suggest some criteria that may facilitate selection best survival rates are associated which should be chosen whenever possible.

参考文章(24)
Masahiro Asakage, Nobutaka Umekita, Yuichi Matsui, Sachio Miyamoto, Masatsugu Kitamura, Akio Saiura, Tsuyoshi Maeshiro, Satoru Inoue, Clinicopathological features and outcome of hepatic resection for liver metastasis from gastric cancer. Hepato-gastroenterology. ,vol. 49, pp. 1062- 1065 ,(2002)
Takashi Matsumata, Shigeki Wakiyama, Ken Shirabe, Yoshihiko Maehara, Kenji Takenaka, Tetsuo Ikeda, Yasuharu Ikeda, Hidefumi Higashi, Keizo Sugimachi, Takuhiro Ezaki, Keishi Kishikawa, Mitsuo Shimada, Shingo Fukuzawa, Yohichi Yakeishi, Ken Ichi Taguchi, Analysis of the prognostic factors for liver metastasis of gastric cancer after hepatic resection: a multi-institutional study of the indications for resection. Hepato-gastroenterology. ,vol. 50, pp. 1560- 1563 ,(2003)
S Ambiru, N Nakajima, M Ohtsuka, M Miyazaki, Y Shimizu, A Togawa, F Kimura, H Shimizu, K Nakagawa, H Itoh, T Suwa, S Yoshioka, K Sasada, M Shiobara, Hepatic resection of liver metastases from gastric carcinoma. The American Journal of Gastroenterology. ,vol. 92, pp. 490- 493 ,(1997)
Hye Rin Roh, Kyung-Suk Suh, Hyuk-Joon Lee, Han-Kwang Yang, Kuk Jin Choe, Kuhn Uk Lee, Outcome of hepatic resection for metastatic gastric cancer American Surgeon. ,vol. 71, pp. 95- 99 ,(2005) , 10.1177/000313480507100201
Keiichi Okano, Takashi Maeba, Ken Ishimura, Yukihiko Karasawa, Fuminori Goda, Hisao Wakabayashi, Hisashi Usuki, Hajime Maeta, Hepatic Resection for Metastatic Tumors From Gastric Cancer Annals of Surgery. ,vol. 235, pp. 86- 91 ,(2002) , 10.1097/00000658-200201000-00011
Hiroshi Imamura, Yutaka Matsuyama, Ryo Shimada, Mitsuru Kubota, Ataru Nakayama, Akira Kobayashi, Hiroshi Kitamura, Toshihiko Ikegami, Shin-ichi Miyagawa, Seiji Kawasaki, A study of factors influencing prognosis after resection of hepatic metastases from colorectal and gastric carcinoma. The American Journal of Gastroenterology. ,vol. 96, pp. 3178- 3184 ,(2001) , 10.1111/J.1572-0241.2001.05278.X
S. S. Ellenberg, W. Sun, Adjuvant Therapy for Gastric Cancer: How Negative Results Can Help Patients Journal of the National Cancer Institute. ,vol. 99, pp. 580- 582 ,(2007) , 10.1093/JNCI/DJK162
Michael D??Angelica, Mithat Gonen, Murray F. Brennan, Alan D. Turnbull, Manjit Bains, Martin S. Karpeh, Patterns of Initial Recurrence in Completely Resected Gastric Adenocarcinoma Annals of Surgery. ,vol. 240, pp. 808- 816 ,(2004) , 10.1097/01.SLA.0000143245.28656.15
Ken Shirabe, Shigeki Wakiyama, Tomonobu Gion, Masayuki Watanabe, Mitsuhiro Miyazaki, Keishi Yoshinaga, Masanori Tokunaga, Takashi Nagaie, Hepatic resection for the treatment of liver metastases in gastric carcinoma: review of the literature. Hpb. ,vol. 8, pp. 89- 92 ,(2006) , 10.1080/13651820500472168
René Adam, Laurence Chiche, Thomas Aloia, Dominique Elias, Rémy Salmon, Michel Rivoire, Daniel Jaeck, Jean Saric, Yves Patrice Le Treut, Jacques Belghiti, Georges Mantion, Gilles Mentha, Association Française de Chirurgie, Hepatic Resection for Noncolorectal Nonendocrine Liver Metastases: Analysis of 1452 Patients and Development of a Prognostic Model Annals of Surgery. ,vol. 244, pp. 524- 535 ,(2006) , 10.1097/01.SLA.0000239036.46827.5F