Management of advanced gastric cancer

作者: Timothy J Price , Jeremy D Shapiro , Eva Segelov , Christos S Karapetis , Nick Pavlakis

DOI: 10.1586/EGH.11.103

关键词: Combination chemotherapyTaxaneAdenocarcinomaMedicinePalliative Radiation TherapyInternal medicineAnthracyclineCancerEvidence-based medicineDocetaxelOncology

摘要: The management of advanced gastric cancer has only evolved a little over the last 15 years: platinum and fluoropyrimidine chemotherapy remains backbone therapy with ongoing debate as to benefit triplet either an anthracycline or taxane. Recently published trials biological agents, in particular those targeting Her2 receptor, have provided some signs improvement. This article summarizes relevant literature, discusses role these well geographical variations use, provides recommendations regarding both 'standard chemotherapy' agents cancer. Given relative lack progress for years, focus next 5 years should be on improved understanding molecular basis cancer, thus allowing rational integration new agents.

参考文章(63)
Kevin P. Weinfurt, Value of High-Cost Cancer Care: A Behavioral Science Perspective Journal of Clinical Oncology. ,vol. 25, pp. 223- 227 ,(2007) , 10.1200/JCO.2006.08.9029
L. Assersohn, G. Brown, D. Cunningham, C. Ward, J. Oates, J.S. Waters, M.E. Hill, A.R. Norman, Phase II study of irinotecan and 5-fluorouracil/leucovorin in patients with primary refractory or relapsed advanced oesophageal and gastric carcinoma Annals of Oncology. ,vol. 15, pp. 64- 69 ,(2004) , 10.1093/ANNONC/MDH007
Daniel G. Haller, Jim Cassidy, Stephen J. Clarke, David Cunningham, Eric Van Cutsem, Paulo M. Hoff, Mace L. Rothenberg, Leonard B. Saltz, Hans-Joachim Schmoll, Carmen Allegra, Joseph R. Bertino, Jean-Yves Douillard, Bengt G. Gustavsson, Gerard Milano, Michael O'Connell, Youcef Rustum, Josep Tabernero, Frank Gilberg, Florin Sirzén, Chris Twelves, Potential Regional Differences for the Tolerability Profiles of Fluoropyrimidines Journal of Clinical Oncology. ,vol. 26, pp. 2118- 2123 ,(2008) , 10.1200/JCO.2007.15.2090
Eric Van Cutsem, Vladimir M. Moiseyenko, Sergei Tjulandin, Alejandro Majlis, Manuel Constenla, Corrado Boni, Adriano Rodrigues, Miguel Fodor, Yee Chao, Edouard Voznyi, Marie-Laure Risse, Jaffer A. Ajani, Phase III Study of Docetaxel and Cisplatin Plus Fluorouracil Compared With Cisplatin and Fluorouracil As First-Line Therapy for Advanced Gastric Cancer: A Report of the V325 Study Group Journal of Clinical Oncology. ,vol. 24, pp. 4991- 4997 ,(2006) , 10.1200/JCO.2006.06.8429
Derek G. Power, David P. Kelsen, Manish A. Shah, Advanced gastric cancer – Slow but steady progress Cancer Treatment Reviews. ,vol. 36, pp. 384- 392 ,(2010) , 10.1016/J.CTRV.2010.01.005
Brigette BY Ma, Edwin P Hui, Tony SK Mok, Population-based differences in treatment outcome following anticancer drug therapies. Lancet Oncology. ,vol. 11, pp. 75- 84 ,(2010) , 10.1016/S1470-2045(09)70160-3
Katherine D Crew, Alfred I Neugut, Epidemiology of gastric cancer World Journal of Gastroenterology. ,vol. 12, pp. 354- 362 ,(2006) , 10.3748/WJG.V12.I3.354
Y.-K. Kang, W.-K. Kang, D.-B. Shin, J. Chen, J. Xiong, J. Wang, M. Lichinitser, Z. Guan, R. Khasanov, L. Zheng, M. Philco-Salas, T. Suarez, J. Santamaria, G. Forster, P.I. McCloud, Capecitabine/cisplatin versus 5-fluorouracil/cisplatin as first-line therapy in patients with advanced gastric cancer: a randomised phase III noninferiority trial Annals of Oncology. ,vol. 20, pp. 666- 673 ,(2009) , 10.1093/ANNONC/MDN717
David Cunningham, Naureen Starling, Sheela Rao, Timothy Iveson, Marianne Nicolson, Fareeda Coxon, Gary Middleton, Francis Daniel, Jacqueline Oates, Andrew Richard Norman, Capecitabine and oxaliplatin for advanced esophagogastric cancer. The New England Journal of Medicine. ,vol. 358, pp. 36- 46 ,(2008) , 10.1056/NEJMC0911925
Maarten L. Janmaat, Mariëlle I. Gallegos-Ruiz, José A. Rodriguez, Gerrit A. Meijer, Walter L. Vervenne, Dick J. Richel, Cees Van Groeningen, Giuseppe Giaccone, Predictive Factors for Outcome in a Phase II Study of Gefitinib in Second-Line Treatment of Advanced Esophageal Cancer Patients Journal of Clinical Oncology. ,vol. 24, pp. 1612- 1619 ,(2006) , 10.1200/JCO.2005.03.4900