Targeting Chemotherapy Resistance in Glioblastoma Through Modulation of ABC Transporters

摘要: Glioblastoma (GBM) is a highly aggressive Grade IV solid central nervous system neoplasm with an incidence rate of 3–4 per 100,000 people worldwide and the average 5-year survival GBM patients less than 5 %, leading to fact that most lethal form brain tumor. The presence several adenosine triphosphate-binding cassette (ABC) transporters thought contribute sustained progression tumours, inhibiting rapidly removing anticancer drugs from tumour cells. ABC are transmembrane pumps which use ATP hydrolysis facilitate translocation substrates across cellular membranes. Overexpression including P-gp (ABCB1), ABCCs, or MRPs breast cancer-resistance protein (BCRP, ABCG2) on cells themselves instill chemoresistance active drug extrusion at tumor site rendering temporal effect successfully administered negligible, if all. In this regard, role individual their contribution potential as targeted therapies chemosensitization will be discussed in chapter.