Selective method based on negative electrospray ionization ion mobility spectrometry for direct analysis of salivary thiocyanate.

作者: M. T. Jafari , M. Javaheri

DOI: 10.1021/AC101017M

关键词: Chemical ionizationIon-mobility spectrometryElectrospray ionizationThiocyanateChlorideChromatographyDetection limitAnalytical chemistryMass spectrometrySolventChemistry

摘要: This study describes a novel technique for direct analysis of thiocyanate in human saliva using negative electrospray-ion mobility spectrometry (ESI-IMS) and without any considerable sample pretreatment. The ESI-IMS system with nearly complete desolvation cannot be useful salivary because overlapping occurs between the format peak solvent peak. In addition, chloride ions existing produce very broad peak, which has drastically interfering effect on SCN− determination. this study, little change operation conditions apparatus (lowering flow rate drift gas), it was possible to overcome these problems. process decreased lower gas, caused separated completely from other interference peaks such as ions. results obtained proposed methodology provide detection limit 0.003 μg/mL linear dynamic range...

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