Present status and perspectives regarding the therapeutic strategy for acute myeloid leukemia, non-Hodgkin's lymphoma and multiple myeloma in the elderly

摘要: The incidence of cancers increases with advancing age. To improve the quality life elderly patients hematological malignancies, appropriate therapeutic approaches have to be provided under adequate informed consent and evaluation prognostic factors that predict outcome each disease. Even in patients, combination chemotherapies are effective for obtaining a good selected populations judged by such as performance status, pre-existing comorbid conditions or disease features; however, non-intensive treatment supportive care might also considered patient groups poor prognosis. Therefore, clinical parameters relevance decisions herein addressed. During cancer treatment, attention must paid presence age-related organ dysfunction, drug resistance, drug-induced side-effects end organ-targeted toxicity, neutropenia due myelosuppression cytotoxic drugs. Current therefore expected compliance better introduction several molecularly targeted therapies, novel nucleoside analogs non-myeloablative stem cell transplantation.