Seven-tesla phase imaging of acute multiple sclerosis lesions: a new window into the inflammatory process.

摘要: Objective In multiple sclerosis (MS), accurate, in vivo characterization of dynamic inflammatory pathological changes occurring newly forming lesions could have major implications for understanding disease pathogenesis and mechanisms tissue destruction. Here, we investigated the potential ultrahigh-field magnetic resonance imaging (MRI; 7T), particularly phase combined with contrast enhancement, to provide new insights acute MS lesions. Methods Sixteen active patients were studied at 7T. Noncontrast, high-resolution T2* magnitude scans, T1 scans before/after gadolinium injection, contrast-enhanced (DCE) acquired. T2*/phase features DCE pattern determined chronic lesions. When possible, 1-year follow-up 7T MRI was performed. Results Of 49 contrast-enhancing lesions, 44 be analyzed. Centrifugal appeared isointense or hypointense on images, whereas centripetal showed thin, rims that clearly colocalized initial site enhancement. This generally disappeared once enhancement resolved. Conversely, 43 also selected presence rims, findings stable over time, typically thicker darker. These considerations suggest different underlying processes 2 lesion types. Interpretation Ultrahigh-field and, especially, contrast, are highly sensitive which differ from patterns seen In rim reflects expanding edge may directly correspond byproducts sequelae blood–brain barrier opening. Ann Neurol 2013;74:669–678