Enhancing Fluoride Mediated Dentine Sensitivity Relief through Functionalised Tricalcium Phosphate Activity

摘要: Background. To assess the clinical efficacy of a dentifrice containing fluoride and functionalised tricalcium phosphate (fTCP) in reducing dentine sensitivity. Methods. A 10-week parallel blind randomised control trial was conducted. Subjects were assigned to one four groups instructed brush twice daily: A: Colgate Cavity Protection (1000 ppmF-MFP); B: Sensodyne Total Care (1000 ppmF-NaF + 19300 ppmK(+)-KNO3); C: Clinpro Tooth Creme (950 ppmF-NaF fTCP); D: (brushing additional topical application). Seventy-one patients assessed at baseline, 6 weeks, 10 weeks for cold, tactile, hypertonic sensitivity using NRS-11 pain rating scale. combined modalities score (CMS) calculated. Results. At reported following reduction CMS: (20%); B (30%); C (42%); D (52%). (18%), (40%), (24%), (54%). The only CMS comparisons show significant difference (P < 0.05) between Groups (6 weeks). Conclusions. Addition fTCP enhances ability Using daily brushing can be as effective reduce Care. However, nightly application fTCP, addition brushing, showed an enhanced