Superior antimetastatic effect of pemetrexed-loaded gelatinase-responsive nanoparticles in a mouse metastasis model.
作者： Nannan Lu , Qin Liu , Rutian Li , Li Xie , Jie Shen
DOI: 10.1097/CAD.0B013E328356DC11
关键词: PEG ratio 、 Gelatinase 、 Nanoparticle 、 Pemetrexed 、 Melanoma 、 Delivery system 、 Metastasis model 、 Cancer research 、 Chemistry 、 Ethylene glycol
摘要: Novel pemetrexed-loaded gelatinase-responsive nanoparticles were prepared as a targeted delivery system to determine its potential for clinical therapy of malignant melanoma. The poly(ethylene glycol)(PEG)–peptide–poly(e-caprolactone) (PCL) included gelatinase-cleav
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