Monocyte deactivation in septic patients: Restoration by IFN-γ treatment

作者: Wolf-Dietrich Döcke , Felix Randow , Uta Syrbe , Dietmar Krausch , Khusru Asadullah

DOI: 10.1038/NM0697-678

关键词: MonocyteTransforming growth factorSepsisMedicineImmunologyProinflammatory cytokineLipopolysaccharideInterferonDownregulation and upregulationTumor necrosis factor alpha

摘要: Neutralization of proinflammatory cytokines, such as tumor necrosis factor-α (TNF-α) or interleukin-1 (IL-1), decreases mortality in several animal models of sepsis. However, recent …

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