Kinematic analysis of left ventricular deformation in myocardial infarction using magnetic resonance cardiac tagging.

摘要: The Magnetic Resonance (MR) tagging technique provides detailed information about 2D motion in the plane of observation. Interpretation this as a reflection 3D entire cardiac wall is major problem. In finite element models mechanics infarcted heart, an region causes motional asymmetry, extending far beyond infarct boundary. Here we present method to quantify such asymmetry inamplitude and orientation. For purpose images short-axis cross-section ejecting left ventricle were acquired from 9 healthy volunteers 5 patients with myocardial infarction. MR-tags applied mm grid at end-diastole. tags tracked by video-image analysis. Tag was fitted kinematic model motion. center cavity displaced same amount(p=0.11) during ejection phase: 3.8 ± 1.4 3.0 0.9 (mean sd), respectively. Cross-sectional rotation decrease cross-sectional area both greater than patients: 6.4 1.5 vs. 0.8 degrees (p<0.001), 945 71 700 176 2 (p=0.02), patients, motion, expressed sine wave dependency contraction around circumference, significantly enlarged (p=0.02). proposed analysis can be used assess deformation humans. We expect that analyzing more cross-sections simultaneously, location degree infarction assessed efficiently.