Linkage of Chromosomal Markers on 4q With a Putative Gene Determining Maximal Insulin Action in Pima Indians

摘要: Insulin action in vivo varies widely nondiabetic Pima Indians. Not all of this variance is attributable to individual differences obesity, physical fitness, sex, or age, and after correcting for these co-variates, measures insulin aggregate families. at maximally stimulating concentrations has a trimodal frequency distribution, particularly among obese individuals. This consistent with the hypothesis that codominantly inherited autosomal gene, unrelated determines MaxM population. Preliminary sib-pair linkage analyses indicated possibility between GYPA/B locus (encoding MNSs red cell surface antigens) on chromosome 4q. To confirm extend findings, 10 additional loci 4q were typed 123 siblings many their parents from 46 nuclear The results indicate significant ( P < 0.001) FABP2 ANX5 MaxM, fasting concentration. No was found markers obesity. Our findings gene 4q, near loci, contributes