A conserved xiap-interaction motif in caspase-9 and smac/diablo for mediating apoptosis
作者： Emad S. Alnemri
DOI:
关键词: Biology 、 Baculoviral IAP repeat-containing protein 3 、 Inhibitor of apoptosis 、 Enhancer 、 Inhibitor of apoptosis domain 、 Caspase-9 、 XIAP 、 Nucleic acid 、 Molecular biology 、 Cell biology 、 Apoptosis
摘要: The invention provides caspase-9-related peptides and polypeptides capable of binding to an Inhibitor Apoptosis Protein (IAP), as well caspase-9 mutant that fail undergo normal processing bind IAP. Nucleic acid molecules, including expression vectors, encoding such are also provided. Such polypeptides, useful for inducing apoptosis identifying inhibitors enhancer apoptosis.
lens.org 参考文章(4)
Srinivasa M. Srinivasula, Ramesh Hegde, Ayman Saleh, Pinaki Datta, Eric Shiozaki, Jijie Chai, Ryung-Ah Lee, Paul D. Robbins, Teresa Fernandes-Alnemri, Yigong Shi, Emad S. Alnemri, A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis Nature. ,vol. 410, pp. 112- 116 ,(2001) , 10.1038/35065125
Rachael A. Kipp, Martin A. Case, Aislyn D. Wist, Catherine M. Cresson, Maria Carrell, Erin Griner, Arun Wiita, Philip A. Albiniak, Jijie Chai, Yigong Shi, Martin F. Semmelhack, George L. McLendon, Molecular Targeting of Inhibitor of Apoptosis Proteins Based on Small Molecule Mimics of Natural Binding Partners Biochemistry. ,vol. 41, pp. 7344- 7349 ,(2002) , 10.1021/BI0121454
Casey W. Wright, Rollie J. Clem, Sequence Requirements for Hid Binding and Apoptosis Regulation in the Baculovirus Inhibitor of Apoptosis Op-IAP Hid BINDS Op-IAP IN A MANNER SIMILAR TO Smac BINDING OF XIAP Journal of Biological Chemistry. ,vol. 277, pp. 2454- 2462 ,(2002) , 10.1074/JBC.M110500200
Zhihong Liu, Chaohong Sun, Edward T. Olejniczak, Robert P. Meadows, Stephen F. Betz, Thorsten Oost, Julia Herrmann, Joe C. Wu, Stephen W. Fesik, Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain Nature. ,vol. 408, pp. 1004- 1008 ,(2000) , 10.1038/35050006