Endocannabinoids: endogenous cannabinoid receptor ligands with neuromodulatory action.
作者： Vincenzo Di Marzo , Dominique Melck , Tiziana Bisogno , Luciano De Petrocellis
DOI: 10.1016/S0166-2236(98)01283-1
关键词: Endorphins 、 Neuroscience 、 Endocannabinoid system 、 Biology 、 Anandamide 、 Cannabinoid receptor 、 Depolarization-induced suppression of inhibition 、 2-Arachidonoylglycerol 、 Cannabinoid 、 Cannabinoid Receptor Modulators
摘要: The existence of an endogenous cannabinoid system was demonstrated conclusively with the discovery brain constituents capable activating receptors functionally. These compounds are synthesized by neuronal cells and inactivated through re-uptake enzymatic hydrolysis both neurons astrocytes. In analogy endorphins they can be referred to as endocannabinoids. Apart from identification their metabolic pathways, research carried out in past six years has focused on possible cellular molecular targets for actions studies have confirmed a similarity between endocannabinoids psychoactive substance marijuana, delta9(-)-tetrahydrocannabinol, suggested role modulation neurotransmitter action release.
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