Dual infection with HIV and malaria fuels the spread of both diseases in sub-Saharan Africa.
作者： L. J. Abu-Raddad , P. Patnaik , J. G. Kublin
关键词: Epidemiology 、 Public health 、 Immunology 、 Malaria 、 Viral load 、 Viral disease 、 Acquired immunodeficiency syndrome (AIDS) 、 Sida 、 Disease
摘要: Mounting evidence has revealed pathological interactions between HIV and malaria in dually infected patients, but the public health implications of interplay have remained unclear. A transient almost one-log elevation viral load occurs during febrile episodes; addition, susceptibility to is enhanced HIV-infected patients. mathematical model applied a setting Kenya with an adult population roughly 200,000 estimated that, since 1980, disease interaction may been responsible for 8,500 excess infections 980,000 episodes. Co-infection might also facilitated geographic expansion areas where prevalence high. Hence, repeated increases resulting from recurrent co-infection be important factor promoting spread sub-Saharan Africa.
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