Lymphocyte migration into the central nervous system: Implication of ICAM-1 signalling at the blood–brain barrier

摘要: Lymphocyte recruitment to the central nervous system (CNS) is a critical step in pathogenesis of diseases such as multiple sclerosis (MS), meningitis and posterior uveitis. The principle sequential stages that control lymphocyte emigration from blood have been widely reported, but only recently has attention directed towards role vascular endothelium actively supporting transvascular migration. It now shown adhesion molecules, particularly those immunoglobulin super family (eg ICAM-1, VCAM-1 PECAM-1), not act ligands for leucocyte receptors can also serve signal transducers. Engagement these initiates endothelial signalling cascades result downstream effector mechanisms which turn influence progression neuroinflammation. In particular, it ICAM-1-mediated brain cells crucial regulatory process migration through blood-brain barrier represents an additional phase multistep paradigm recruitment. this article we review current understanding cell ICAM-1 discuss importance findings relation trafficking CNS.