The unfolded protein response as a target for anticancer therapeutics.

摘要: The endoplasmic reticulum (ER) is an essential organelle in eukaryotic cells, responsible for protein synthesis, folding, sorting, and transportation. ER stress initiated when the unfolded or misfolded load exceeds capacity of to properly fold protein. Tumor microenvironmental conditions, such as nutrient deprivation, hypoxia, oxidative perturb folding trigger chronic stress. Cancer cells can tolerate mild stress, however, persistent severe kills cancer by inducing their autophagy, apoptosis, necroptosis, immunogenic cell death. Based on this rationale, many drugs have been developed triggering irremediable targeting various processes secretory pathway. This review discusses mechanisms ER, key signaling cassettes that are involved response, correlation with formation progression. Importantly, current experimental FDA approved anti-cancer induce emerging targets within pathway development new anticancer drugs.