Islet dynamics: a glimpse at beta cell proliferation.

摘要: Pancreatic islets consist of 60-80% beta cells, which secrete insulin, a hormone profound importance in the regulation carbohydrate, fat and protein metabolism. Beta cell death and/or dysfunction result an insufficient amount insulin that leads to high glucose levels blood, metabolic disorder known as Diabetes mellitus. Many studies aiming establish new therapeutic applications for this are targeted at understanding manipulating mechanisms proliferation function. The present comprehensive review summarizes advances field renewal focuses on three fundamental issues: (i) identification cellular origins cells adult, (ii) proliferation, (iii) downstream signaling events controlling cycle machinery. Although source adult is still being debated, recent findings mice show important contribution mass. In conjunction with describing characterized mitogens components machinery, we discuss how proliferative potential could provide novel methods expanding Such expansion be achieved either through vitro systems, where functional generated, propagated further used transplantation, or vivo, directed from sources organism. Once established, these would have benefits diabetic patients