Regulation of angiotensin converting enzyme.

摘要: Angiotensin converting enzyme (ACE;EC 3.4.15.1), or kininase II, was studied in serum, cultured endothelial cells from cord artery, macrophages of humans, and serum purified plasma membranes rats following treatment with inducers ACE biosynthesis. activity measured biological fluids an kinetic method employing synthetic 1-hipp-1-his-l-leu tripeptide as a substrate, new using 125I-labelled specific inhibitor sensitive probe for binding sites. The latter technique also proved suitable the quantification cells. Anti-human antibody employed immunofluorescence studies human Dexamethasone caused increase cells, rat pulmonary membranes, but failed to rats. Captopril enalapril hypertensive patients increased total ACE, being evident after removal active drug by prolonged storage chloramine T (captopril) dialysis (enalapril). content macrophages. Macrophages appeared captopril induction biosynthesis pre-stimulation Escherichia coli lipopolysaccharide. potentiated known tissue. Thus may be enhanced three categories treatment: (1) glucocorticoid; (2) macrophage activation; (3) inhibitors. precise mechanism its possible relevance await further clarification.