Increased cerebral activity suppresses baroreflex control of heart rate in freely moving mice.

摘要: We assessed whether increased cerebral activity suppressed baroreflex control of heart rate (HR) and, if so, this occurred prior to the onset locomotion in daily mice. measured mean arterial pressure (MAP, catheter), blood flow motor cortex (CBF, laser-Doppler flowmetry), and electroencephalogram free-moving mice (n= 8) during 12 daytime hours. The contribution HR MAP regulation was determined a total resting period for ∼8 h from cross-correlation function (R(t)) between spontaneous changes (ΔHR) (ΔMAP) every 4 s sensitivity ΔHR/ΔMAP where R(t) significant (P < 0.05). power density ratio θ δ wave band (θ/δ), as an index activity, positively correlated with CBF 73 ± 3% 0.05) 59 2% When each measurement divided into seven bins according level θ/δ, 91 lowest bin 118 highest 0.001), −0.69 0.06 −0.27 0.04 0.001) (beats min−1 mmHg−1) −12.4 0.9 −7.5 respectively, correlations θ/δ (all P 0.002). Moreover, started move ∼30 sec after sequential increases R(t), at 5 times higher probability than given time, followed by rapid increase ∼10 mmHg. These results suggest that suppresses might be related start voluntary MAP.