Use of a racemic derivatizing agent for measurement of enantiomeric excess by circular dichroism spectroscopy
作者： Tetsutaro Hattori , Yuji Minato , Sulan Yao , M.G Finn , Sotaro Miyano
DOI: 10.1016/S0040-4039(01)01707-5
关键词: Chloride 、 Enantiomeric excess 、 Organic chemistry 、 Chemistry 、 Amine gas treating 、 Kinetic resolution 、 Enantiomer 、 Circular dichroism 、 Acylation 、 Derivatization 、 Biochemistry 、 Drug discovery
摘要: Abstract Enantiomeric excesses of several alcohols and an amine have been determined by derivatization with racemic 2′-methoxy-1,1′-binaphthyl-2-carbonyl chloride rac-1 , no requirement for kinetic resolution in the acylation step. The necessary information is provided instead CD UV spectra derived esters amides, chiral signal being dominated binaphthyl component.
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