Evolution of the Regulatory Control of the Vertebrate Heart: The Role of the Contractile Proteins
作者： Todd E. Gillis
DOI: 10.1007/978-1-4614-3387-3_6
关键词: Cardiac cycle 、 Cell biology 、 Endoplasmic reticulum 、 Protein kinase A 、 Chemistry 、 Contraction (grammar) 、 Troponin I 、 Cardiac function curve 、 Actin 、 Anatomy 、 Myocyte
摘要: The contraction of the vertebrate heart is initiated when intercellular Ca2+ increases and binds to contractile element via cardiac troponin C (cTnC). activation cTnC triggers a series conformational changes through components thin filament that results in generation force by myocyte. While all contractions are powered this mechanism, comparison function between species reveals significant variation. This includes differences rate, strength as well regulatory ability. purpose work examine functional basis for such how these have evolved within heart. I (cTnI) myosin-binding protein (cMyBP-C) they regulated kinase A (PKA) specifically examined. (PKA activated following β-adrenergic stimulation.) influence evolution endothermy on also considered. analysis completed integration variety studies looked at hearts different utilized phylogenetic approaches specific proteins. It generally found became more complex both anatomy capacity, sequence enabled greater control reaction. In addition, appears driven proteins including cTnI.
springer.com
springerlink.com参考文章(54)
M. Gautel, O. Zuffardi, A. Freiburg, S. Labeit, Phosphorylation switches specific for the cardiac isoform of myosin binding protein-C: a modulator of cardiac contraction? The EMBO Journal. ,vol. 14, pp. 1952- 1960 ,(1995) , 10.1002/J.1460-2075.1995.TB07187.X
W. Burggren, A. Farrell, H. Lillywhite, Vertebrate Cardiovascular Systems Comprehensive Physiology. pp. 215- 308 ,(2011) , 10.1002/CPHY.CP130104
Imants George Priede, The effect of swimming activity and section of the vagus nerves on heart rate in rainbow trout. The Journal of Experimental Biology. ,vol. 60, pp. 305- 319 ,(1974) , 10.1242/JEB.60.2.305
A. M. Gordon, E. Homsher, M. Regnier, Regulation of Contraction in Striated Muscle Physiological Reviews. ,vol. 80, pp. 853- 924 ,(2000) , 10.1152/PHYSREV.2000.80.2.853
A. Weisberg, S. Winegrad, Alteration of myosin cross bridges by phosphorylation of myosin-binding protein C in cardiac muscle. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 93, pp. 8999- 9003 ,(1996) , 10.1073/PNAS.93.17.8999
T. E. Gillis, J. M. Klaiman, The influence of PKA treatment on the Ca2+ activation of force generation by trout cardiac muscle. The Journal of Experimental Biology. ,vol. 214, pp. 1989- 1996 ,(2011) , 10.1242/JEB.052084
Morten Zaar, Johannes Overgaard, Hans Gesser, Tobias Wang, Contractile properties of the functionally divided python heart: two sides of the same matter. Comparative Biochemistry and Physiology A-molecular & Integrative Physiology. ,vol. 146, pp. 163- 173 ,(2007) , 10.1016/J.CBPA.2006.10.015
Martina Krüger, Wolfgang A. Linke, Titin-based mechanical signalling in normal and failing myocardium. Journal of Molecular and Cellular Cardiology. ,vol. 46, pp. 490- 498 ,(2009) , 10.1016/J.YJMCC.2009.01.004
Thomas A. Noland,, Robert L. Raynor, Nathan M. Jideama, Xiaodu Guo, Marcelo G. Kazanietz, Peter M. Blumberg, R. John Solaro, J. F. Kuo, Differential regulation of cardiac actomyosin S-1 MgATPase by protein kinase C isozyme-specific phosphorylation of specific sites in cardiac troponin I and its phosphorylation site mutants. Biochemistry. ,vol. 35, pp. 14923- 14931 ,(1996) , 10.1021/BI9616357
Helen M. Rarick, Hai-ping Tang, Xiao-du Guo, Anne F. Martin, R.John Solaro, Interactions at the NH2-terminal interface of cardiac troponin I modulate myofilament activation. Journal of Molecular and Cellular Cardiology. ,vol. 31, pp. 363- 375 ,(1999) , 10.1006/JMCC.1998.0870