Mechanistic Switch via Subtle Ligand Modulation: Palladium-Catalyzed Synthesis of α,β-Substituted Styrenes via CH Bond Functionalization
作者： Areli Flores-Gaspar , Ruben Martin
关键词: Catalysis 、 Chemical synthesis 、 Stereoselectivity 、 Carbon–hydrogen bond activation 、 Palladium 、 Stereochemistry 、 Regioselectivity 、 Chemical bond 、 Chemistry 、 Ligand
摘要: A new catalyst system able to efficiently perform the synthesis of styrenes via C—H bond functionalization and a subtle ligand modification are described. The high level activity achieved allows for highly functionalized α,β-substituted styrenes, even elusive E-configured trisubstituted olefins, in regio- stereoselective manner. Mechanistic experiments allowed identification corresponding synthetic intermediates.
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