Design of Hollow Hyaluronic Acid Cylinders for Sustained Intravitreal Protein Delivery

摘要: A hollow cylinder intravitreal implant was developed to achieve sustained release of protein the retina for treatment retinal diseases. Hollow cylinders were fabricated by molding and cross-linking hyaluronic acid, major component vitreous humor. filled with a concentrated solution, properties walls tested. Cross-linked acid hydrogels swelling degrees as low 2.7 achieved means extend protein. capable releasing an antigen-binding fragment over 4 months at maximum rate μg per day. Protein from modeled using COMSOL Multiphysics® software, diffusion coefficients between 1.0 × 10-11 3.0 cm2/s yielded therapeutically effective levels Cylinders 1 mm outer radius loading >1 mg while least 2.5 day 4.5 months. Although smaller facilitate placement, decreasing severely limited drug loading. Design implants must balance high reduce device size control coefficient sustain release.