Childhood Cancer Among Alaska Natives

摘要: Objective. The primary purpose of this study was to examine the occurrence cancer in Alaska Native (AN) children (under age 20). Although several studies have compared differences incidence between white and black children, few examined among Natives/American Indians. We know no published article describing AN children. our findings with those American Indian New Mexico Data on mortality, survival, prevalence are also included. is term used collectively for inhabitants whose ancestors occupied area before European contact what now state Alaska. Natives include Eskimo, Indian, Aleut groups. 3 major groups differ culture, language, probably genetics, there similarities numerous social economic indicators. Northern Eskimo (Inupiat) related Canadian Greenland Inuit. Indians Athabaskan (in interior state), who share commonalities as well Navajo Apache southwestern United States. Tlingit, Haida, Tsimshian reside primarily southeast panhandle state. similar British Columbia. Methods. from Tumor Registry, 1969–1996. studied under 20 make results comparable national data presented National Cancer Institute’s Surveillance, Epidemiology End Results (SEER) Pediatric Monograph. Population based census Health Service intercensal estimates. US whites SEER program. Calculations were made using SEERStat software. years 1996–2000. (The Registry has collected all Alaskans only since 1996). Odds ratios (ORs) rates 95% confidence intervals (CIs) calculated. Results. rate (both sexes) cancers combined that (OR: 1.0; CI: 0.8–1.1). Examination childhood by ethnicity, however, reveal significantly lower 0.6; 0.4–0.8) but not different or For most International Classification Childhood Cancers groups, whites. However, at higher risk hepatic tumors 13.1; 7.9–20.5), particularly hepatocellular carcinoma 43.8; CI:24.4–75.1) retinoblastoma 2.8; 1.3–5.3). By ethnic group, high Eskimo. Rates neuroblastoma 0.1; 0.1–0.6) lymphoma 0.5; 0.3–0.9), Hodgkin’s disease 0.2; 0.0–0.5). On basis 5 data, do seem Because whites, we reviewed other relevant populations, specifically registry. Using software, calculated Mexican (NMAI) them rates. NMAI than 0.8). 2.5; CI:1.4–4.5). Similar AN, be low 0.1–0.7), a group 0.0–0.3), and, specifically, 0.0–0.4). central nervous system 0.3–0.7). average annual age-adjusted mortality (28.6 vs 37.3 per million). Conclusions. Comparison NMAI. Differences exist select striking found tumors, largely because elevated hepatitis B-associated carcinoma. All B antigen positive. A statewide virus immunization program begun late 1982. 16 born 1983 developed carcinoma, instituted infants received diagnosis significant difference. Comparing after removing cases both populations an OR 0.8 (95% 0.7–1.0). Thus, if increase occurs coming generations, then may soon lymphomas, very disease. neuroblastoma. It reassuring excess increasing. There concern population regarding environmental exposure, including ionizing radiation. Our show leukemia thyroid cancers, malignancies which radiation known risk.