Natural Products as Anticancer Agents
作者： David G. I. Kingston , David J. Newman
DOI: 10.1002/9780470048672.WECB369
关键词: Vinblastine 、 Combinatorial chemistry 、 Mechanism of action 、 Paclitaxel 、 Biology 、 Pharmacology 、 Clinical Practice
摘要: Natural products have provided some of the most effective drugs for treatment cancer, including such well-known as paclitaxel (Taxol™; Bristol-Myers Squibb) adriamycin, vinblastine, and vincristine. also many compounds that led to discovery new biochemical mechanisms. This review summarizes major natural in clinical use today introduces several ones on cusp entering practice. The is organized by mechanism action, with interact proteins discussed first, followed RNA or DNA.
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