Tissue Tolerable Plasma and Polihexanide: Are Synergistic Effects Possible to Promote Healing of Chronic wounds? In Vivo and In Vitro Results

作者: Claudia P. Bender , Nils-Olaf Hübner , Klaus-Dieter Weltmann , Christian Scharf , Axel Kramer

DOI: 10.1007/978-94-007-2852-3_25

关键词: CytotoxicityPlasma treatmentPharmacologyChronic woundIn vitroIn vivoWound healingPathologyAntisepticCell integrity

摘要: The assumption is that tissue tolerable plasma works as promoter for wound healing and can be beneficially combined with the antiseptic polihexanide to avoid bacterial recolonization. effects of a – (PHMB) application on cell integrity, cytotoxicity its irritative inflammative potential were tested in vitro two dogs vivo.

参考文章(28)
Claudia Bender, Rutger Matthes, Eckhard Kindel, Axel Kramer, Jürgen Lademann, Klaus-Dieter Weltmann, Werner Eisenbeiß, Nils-Olaf Hübner, The Irritation Potential of Nonthermal Atmospheric Pressure Plasma in the HET‐CAM Plasma Processes and Polymers. ,vol. 7, pp. 318- 326 ,(2010) , 10.1002/PPAP.200900119
Stephen C. Davis, Carlos Ricotti, Alex Cazzaniga, Esperanza Welsh, William H. Eaglstein, Patricia M. Mertz, Microscopic and physiologic evidence for biofilm-associated wound colonization in vivo. Wound Repair and Regeneration. ,vol. 16, pp. 23- 29 ,(2008) , 10.1111/J.1524-475X.2007.00303.X
A. Hammann, N.-O. Huebner, C. Bender, A. Ekkernkamp, B. Hartmann, P. Hinz, E. Kindel, I. Koban, S. Koch, T. Kohlmann, J. Lademann, R. Matthes, G. Müller, R. Titze, K.-D. Weltmann, A. Kramer, Antiseptic Efficacy and Tolerance of Tissue-Tolerable Plasma Compared with Two Wound Antiseptics on Artificially Bacterially Contaminated Eyes from Commercially Slaughtered Pigs Skin Pharmacology and Physiology. ,vol. 23, pp. 328- 332 ,(2010) , 10.1159/000314724
N.-O. Hübner, R. Matthes, I. Koban, C. Rändler, G. Müller, C. Bender, E. Kindel, T. Kocher, A. Kramer, Efficacy of chlorhexidine, polihexanide and tissue-tolerable plasma against Pseudomonas aeruginosa biofilms grown on polystyrene and silicone materials. Skin Pharmacology and Physiology. ,vol. 23, pp. 28- 34 ,(2010) , 10.1159/000318265
Y. Poumay, F. Dupont, S. Marcoux, M. Leclercq-Smekens, M. H�rin, A. Coquette, A simple reconstructed human epidermis: preparation of the culture model and utilization in in vitro studies Archives of Dermatological Research. ,vol. 296, pp. 203- 211 ,(2004) , 10.1007/S00403-004-0507-Y
Srdjan Stepanović, Vladimir Dimitrijević, Dragana Vuković, Ivana Dakić, Branislava Savić, Milena Švabic-Vlahović, Staphylococcus sciuri as a part of skin, nasal and oral flora in healthy dogs. Veterinary Microbiology. ,vol. 82, pp. 177- 185 ,(2001) , 10.1016/S0378-1135(01)00377-7
Geoff Lloyd, Gary Friedman, Syed Jafri, Greg Schultz, Alex Fridman, Keith Harding, Gas Plasma: Medical Uses and Developments in Wound Care Plasma Processes and Polymers. ,vol. 7, pp. 194- 211 ,(2010) , 10.1002/PPAP.200900097
Ina Koban, Rutger Matthes, Nils-Olaf Hübner, Alexander Welk, Peter Meisel, Birte Holtfreter, Rabea Sietmann, Eckhard Kindel, Klaus-Dieter Weltmann, Axel Kramer, Thomas Kocher, Treatment of Candida albicans biofilms with low-temperature plasma induced by dielectric barrier discharge and atmospheric pressure plasma jet New Journal of Physics. ,vol. 12, pp. 073039- ,(2010) , 10.1088/1367-2630/12/7/073039
Julia Scheel, Marcus Kleber, Jürgen Kreutz, Elke Lehringer, Annette Mehling, Kerstin Reisinger, Winfried Steiling, Eye irritation potential: usefulness of the HET-CAM under the Globally Harmonized System of classification and labeling of chemicals (GHS). Regulatory Toxicology and Pharmacology. ,vol. 59, pp. 471- 492 ,(2011) , 10.1016/J.YRTPH.2011.02.003
J.E. Rubin, M. Chirino-Trejo, Pharyngeal, rectal and nasal colonization of clinically healthy dogs with Staphylococcus aureus. Veterinary Microbiology. ,vol. 143, pp. 440- 441 ,(2010) , 10.1016/J.VETMIC.2009.11.012