Two Surface-Exposed Elements of the B30.2/SPRY Domain as Potency Determinants of N-Tropic Murine Leukemia Virus Restriction by Human TRIM5α
作者： Michel J. Perron , Matthew Stremlau , Joseph Sodroski
DOI: 10.1128/JVI.00219-06
关键词: Capsid 、 Gammaretrovirus 、 Virus 、 Peptide sequence 、 Virology 、 Biology 、 Molecular biology 、 Potency 、 Murine leukemia virus 、 Residue (chemistry) 、 Domain (ring theory)
摘要: Human TRIM5α (TRIM5αhu) potently restricts N-tropic (N-MLV), but not B-tropic, murine leukemia virus in a manner dependent upon residue 110 of the viral capsid. Rhesus monkey (TRIM5αrh) inhibits N-MLV only weakly. The study human-monkey chimerae revealed that both v1 and v3 variable regions B30.2/SPRY domain contain potency determinants for restriction. These are predicted to be surface-exposed elements on one face B30.2 domain. Acidic residues complement basic results support recognition retroviral capsid by
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