Evaluation of the genetic basis of tricuspid valve dysplasia in Labrador Retrievers

摘要: Objective—To quantify inheritance of tricuspid valve dysplasia (TVD) in a population Labrador Retrievers and evaluate the possibility effect major locus on TVD. Animals—521 (345 with known phenotypes 176 related dogs unknown phenotypes). Procedure—Dogs were considered normal, equivocal, affected for TVD basis echocardiographic appearance valves. Information was collected estimation heritability 3 categories phenotype, using threshold model. Complex segregation analysis performed to Results—Heritability this found be 0.71, value sufficiently large suggest segregating locus. Subsequent complex did not provide strong evidence indicate influence prevalence However, 2 pheno...