The effect of naringenin on the role of nuclear factor (erythroid-derived 2)-like2 (Nrf2) and haem oxygenase 1 (HO-1) in reducing the risk of oxidative stress-related radiotoxicity in the spleen of rats.
作者： Nadia Abdel‐Magied , Shereen M. Shedid
DOI: 10.1002/TOX.22745
关键词: Naringenin 、 Oxidative stress 、 Glutathione 、 Superoxide dismutase 、 Spleen 、 Endocrinology 、 Internal medicine 、 Malondialdehyde 、 Catalase 、 Glutathione peroxidase 、 Chemistry
摘要: The present study was to evaluate the radiomitigative effect of naringenin (NRG) on modulation ionizing radiation (IR)-induced spleen injury. Rats were exposed 12 Gy (3Gy/two times/week). NRG (50mg/Kg), orally given one hour after first dose, and daily continued during irradiation period. sacrificed 1 day last dose radiation. showed a significant decrease malondialdehyde, hydrogen peroxide with elevation superoxide dismutase, catalase glutathione peroxidase activities content. Moreover, confirmed intracellular defense mechanisms through activation nuclear factor (erythroid-derived 2)-like2 (Nrf2) haem oxygenase-1 (HO-1) levels their protein expression. In addition, deactivated factor-κB (NF-κB) reduced pro-inflammatory cytokines. Further, positive in haematological values (WBCs, RBCs, Hb, Hct% PLt). conclusion, these results suggested that reversed IR-induced redox-imbalance rat spleen.
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