Manganese inhibits mitochondrial aconitase: a mechanism of manganese neurotoxicity

作者: Wei Zheng , Sean Ren , Joseph H. Graziano

DOI: 10.1016/S0006-8993(98)00481-8

关键词: Intraperitoneal injectionMitochondrionEnzyme assayRespiratory chainInternal medicineToxicityNeurotoxicityAconitaseEndocrinologyBiologyBiochemistrySubstantia nigra

摘要: … was associated with the divalent oxidation species of Mn 2+ , … vivo Mn studies demonstrate a brain region-specific reduction … exposure to Mn in rats produces a low Mn concentration in …

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