Ras oncogene mediated induction of a 92kDa metalloproteinase; strong correlation with the malignant phenotype
作者： M. Ballin , D.E. Gomez , C.C. Sinha , U.P. Thorgeirsson
DOI: 10.1016/0006-291X(88)90215-X
关键词: Molecular biology 、 Oncogene 、 Metastasis 、 In vitro 、 Cell culture 、 Enzyme 、 Biology 、 Cell 、 Type IV collagen 、 Metalloproteinase 、 Biophysics 、 Cell biology 、 Biochemistry
摘要: We have previously demonstrated that activated ras oncogenes can induce the metastatic phenotype and type IV collagenolytic activity in NIH3T3 cells (Thorgeirsson et al. Mol. Cell. Biol. 5:259–262, 1985). The present study demonstrates ras-mediated induction of a 92kDa metalloproteinase, which degrades gelatin collagen. Association proteinase expression with malignant was also observed human tumor cell lines. Our data indicate gelatin-collagen degrading metalloproteinase is an important participant proteolytic process involving invasion metastasis.
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