Factor V Leiden (G1691A), Factor V R2 (A4070G) , and Prothrombin (G20210A) Genetic Polymorphisms in Macedonian Patients with Occlusive Artery Disease and Deep Vein Thrombosis
作者： Igor Spiroski , Sashko Kedev , Olivija Efinska-Mladenovska
DOI: 10.3889/SEEJCA.2015.30001
关键词: Thrombosis 、 Surgery 、 Deep vein 、 Factor V 、 Venous thrombosis 、 Allele frequency 、 Prothrombin G20210A 、 Medicine 、 Factor V Leiden 、 Odds ratio 、 Gastroenterology 、 Internal medicine
摘要: AIM: The aim was to analyze association of Factor V Leiden (G1691A), R2 (A4070G) , and Prothrombin (G20210A) Genetic Polymorphism in Macedonian Patients with Occlusive Artery Disease (OAD) Deep Vein Thrombosis (DVT). METHODS: Investigated groups consists 82 healthy, 76 patients OAD, 67 DVT. Blood samples were collected after written consent, DNA isolated from peripheral blood leukocytes. Identification done CVD StripAssay (ViennaLab, Labordiagnostica GmbH, Austria). population genetics analysis package, PyPop, used for the data. Pearson's P -values, crude Odds Ratio Wald’s 95% CI calculated. RESULTS: frequency G allele 0.976 healthy participants, 0.954 0.948 A is highest participants (0.951), smaller DVT (0.918), smallest OAD (0.908). prothrombin 0.980 0.978 Test neutrality (Fnd) showed positive value, but not significantly different 0. genotypes Hardy Weinberg proportions. Any genetic polymorphism Macedonians found. CONCLUSION: We conclude that significant (A4070G), occlusive artery disease or deep venous thrombosis
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