Oxaliplatin in the Treatment of Colorectal Cancer

摘要: Oxaliplatin is one member of a class antineoplastic agents distinguished by the presence platinum complex containing 1,2-diaminocyclohexane (DACH) carrier ligand (Fig. 1). In 1970s, these drugs were found to be active in cisplatin-resistant cell lines (1). part, because first this tested, tetraplatin, had an unfavorable toxicity profile phase I studies, little further study DACH—platinum compounds occurred 1970s (2). During 1980s, George Mathe at Hopital Paul Brousse performed vitro experiments that led him initiate human trials with oxaliplatin. These provided indications drug’s potential clinical utility (3).