Glucose-regulated protein 94 is a novel glioma biomarker and promotes the aggressiveness of glioma via Wnt/β-catenin signaling pathway
作者： Tieyi Hu , Niqi Xie , Chuan Qin , Jiasheng Wang , Yi You
DOI: 10.1007/S13277-015-3635-4
关键词: Glioma 、 Cell growth 、 U87 、 Cell biology 、 Biology 、 Signal transduction 、 Wnt signaling pathway 、 LRP5 、 Cell migration 、 Gene silencing
摘要: Malignant glioma is the most common type of primary brain tumor and represents one aggressive lethal human cancer types. Glioma recurrence a event; however, relevant molecular mechanisms in this setting are not well-understood. In study, we investigated glucose-regulated protein 94 (GRP94) expressions aimed to determine roles GRP94 expression affects cell proliferation, invasion, regulatory signaling U87 cells. Our results showed that was overexpressed at both mRNA levels high-grade glioblastoma as compared with normal tissues. High also predict shorter overall survival patients. RNAi-mediated silencing suppressed cellular colony formation ability Depletion inhibited migration invasion cell. Furthermore, gene microarray analysis revealed depletion caused dysregulation critical pathway, Wnt/β-catenin pathway. We next demonstrated regulates pathway promote proliferation Conclusion, our findings establish progression markers druggable targets glioblastoma, relating their oncogenic effects activation
springer.com
sci-hub.se 参考文章(23)
Josette Brière, Karen Leroy, Fritz Offner, Sofie Lust, Jerina Boelens, Jean-Philippe Jais, Barbara Vanhoecke, Ilse Beck, Heleen Van Melckebeke, Jan Philippé, Marc Bracke, Fabrice Jardin, ER stress in diffuse large B cell lymphoma: GRP94 is a possible biomarker in germinal center versus activated B-cell type Leukemia Research. ,vol. 37, pp. 3- 8 ,(2013) , 10.1016/J.LEUKRES.2012.08.017
Adam S. Duerfeldt, Laura B. Peterson, Jason C. Maynard, Chun Leung Ng, Davide Eletto, Olga Ostrovsky, Heather E. Shinogle, David S. Moore, Yair Argon, Christopher V. Nicchitta, Brian S. J. Blagg, Development of a Grp94 inhibitor Journal of the American Chemical Society. ,vol. 134, pp. 9796- 9804 ,(2012) , 10.1021/JA303477G
Biquan Luo, Chun-Chih Tseng, Gregor B. Adams, Amy S. Lee, Deficiency of GRP94 in the Hematopoietic System Alters Proliferation Regulators in Hematopoietic Stem Cells Stem Cells and Development. ,vol. 22, pp. 3062- 3073 ,(2013) , 10.1089/SCD.2013.0181
Deyou Tao, Yihong Pan, Guobin Jiang, Hongsheng Lu, Song Zheng, Hui Lin, Feilin Cao, B-Myb regulates snail expression to promote epithelial-to-mesenchymal transition and invasion of breast cancer cell Medical Oncology. ,vol. 32, pp. 412- ,(2015) , 10.1007/S12032-014-0412-Y
Nicolas Dejeans, Christophe Glorieux, Samuel Guenin, Raphael Beck, Brice Sid, Rejane Rousseau, Bettina Bisig, Philippe Delvenne, Pedro Buc Calderon, Julien Verrax, Overexpression of GRP94 in breast cancer cells resistant to oxidative stress promotes high levels of cancer cell proliferation and migration: Implications for tumor recurrence Free Radical Biology and Medicine. ,vol. 52, pp. 993- 1002 ,(2012) , 10.1016/J.FREERADBIOMED.2011.12.019
Mingfu Yang, Yong Pan, Yue Zhou, Depletion of ALX1 causes inhibition of migration and induction of apoptosis in human osteosarcoma Tumor Biology. ,vol. 36, pp. 5965- 5970 ,(2015) , 10.1007/S13277-015-3271-Z
J R Molina, N K Agarwal, F C Morales, Y Hayashi, K D Aldape, G Cote, M-M Georgescu, PTEN, NHERF1 and PHLPP form a tumor suppressor network that is disabled in glioblastoma. Oncogene. ,vol. 31, pp. 1264- 1274 ,(2012) , 10.1038/ONC.2011.324
Lili Jiang, Jueheng Wu, Yi Yang, Liping Liu, Libing Song, Jun Li, Mengfeng Li, Bmi-1 promotes the aggressiveness of glioma via activating the NF-kappaB/MMP-9 signaling pathway BMC Cancer. ,vol. 12, pp. 406- 406 ,(2012) , 10.1186/1471-2407-12-406
Alexander Rebl, Andreas Brietzke, Tom Goldammer, Hans-Martin Seyfert, GRP94 is encoded by two differentially expressed genes during development of rainbow trout (Oncorhynchus mykiss). Fish Physiology and Biochemistry. ,vol. 40, pp. 1917- 1926 ,(2014) , 10.1007/S10695-014-9979-7
Nassim Dali-Youcef, Sébastien Froelich, François-Marie Moussallieh, Salvatore Chibbaro, Georges Noël, Izzie J. Namer, Sami Heikkinen, Johan Auwerx, Gene expression mapping of histone deacetylases and co-factors, and correlation with survival time and 1H-HRMAS metabolomic profile in human gliomas. Scientific Reports. ,vol. 5, pp. 9087- 9087 ,(2015) , 10.1038/SREP09087