Cytokine-activated human endothelial cells synthesize and secrete a monocyte chemoattractant, MCP-1/JE.
作者： J S Pober , B J Rollins , T Yoshimura , E J Leonard
DOI:
关键词: Chemotaxis 、 Biology 、 Cytokine 、 Monocyte 、 Tumor necrosis factor alpha 、 CCL8 、 Inflammation 、 Endothelium 、 Chemoattractant activity 、 Molecular biology
摘要: We have demonstrated inducible expression of the mRNA encoding monocyte chemoattractant MCP-1, human homolog JE gene, in endothelial cells within 3 hours treatment with IL-1 beta and tumor necrosis factor. IFN-gamma also induced this after 24 hours, but to a lesser extent. MCP-1/JE protein steadily accumulated medium during 48-hour exposure beta. Medium conditioned by beta-treated contained activity that was immunoadsorbed anti-MCP-1 antibodies. These results suggest secrete chemoattractant, MCP-1/JE, response inflammatory mediators, thus may contribute accumulation monocytes at sites inflammation.
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