Cumulative renal tubular damage associated with cisplatin nephrotoxicity.
作者： Marshall P. Goren , Reba K. Wright , Marc E. Horowitz
DOI: 10.1007/BF00253068
关键词: Internal medicine 、 Excretion 、 Endocrinology 、 Nephrotoxicity 、 Cisplatin 、 Urology 、 Proteinuria 、 Chemistry 、 Creatinine 、 Alanine aminopeptidase 、 Urinary system 、 Toxicity
摘要: We assessed the acute and chronic effect of multiple courses cisplatin therapy on renal tubules by monitoring urinary excretion alanine aminopeptidase, N-acetyl-β-D-glucosaminidase, total protein. Urine specimens were obtained before after doses (90 mg/m2) given to 12 patients. Each dose induced transient increases in enzyme excretion, followed proteinuria 3–5 days later. Transient enzymuria last was significantly greater than that first dose. Moreover, persistent N-acetyl-β-D-glucosaminidase serum creatinine concentrations over pretherapy levels indicated tubular damage. Our findings disclosed striking differences between patients susceptibility progressive nephrotoxicity.
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