Potentiation of the anti-tumour effect of hyperthermia by combining with the vascular targeting agent 5,6-dimethylxanthenone-4-acetic acid.

摘要: The potential of the vascular targeting agent 5,6-dimethylxanthenone-4-acetic acid (DMXAA) to enhance effect hyperthermia was investigated in a C3H mouse mammary carcinoma grown feet female CDF1 mice and normal foot skin. DMXAA, when injected intraperitoneally restrained non-anaesthetized animals, reduced tumour perfusion, as measured using RbCl extraction procedure, increased necrosis histological section, but these effects were dependent on drug dose time interval. At 20mg/kg, it significantly enhanced thermal damage this tumour, given 1h or more before start heating, assessed by growth assay. This enhancement became larger with increasing interval between two treatments. No thermo-potentiation seen at doses 10mg/kg lower. These combined seem be associated shut-down DMXAA. Thermal potentiation DMXAA also heating temperature, greater enhanc...