Alcohol and Fatty Acid Ethyl Esters

摘要: This chapter discusses the relationship of alcohol and fatty acid ethyl esters. Fatty Acid Ethyl Esters (FAEE) are nonoxidative ethanol metabolites that esterification products acids ethanol. FAEE directly contribute to cell injury induced by abuse, but exact mechanism which mediate this toxic effect remains be discovered. Most enzyme activities found catalytic for synthesis enzymes link or acyl-CoA However, there a number reports suggest hydrolysis from more complex lipid molecule (such as phospholipid triglyceride) is rate limiting step in formation FAEE, presumably either nonrate-limiting nonenzymatic. growing importance toxicity excess intake. There an increasing evidence mediated cytotoxicity proving robust marker intake variety cells tissues, blood. The use monitor identify individuals chronic alcoholics should continue strengthen clinical studies completed.