Lower cognitive function in the presence of obesity and hypertension: the Framingham heart study

摘要: OBJECTIVE: To determine the independent effects of obesity and hypertension on cognitive functioning. METHODS: Using a prospective design, male (n=551) female (n=872) participants Framingham Heart Study were classified by presence or absence based data collected over an 18-y surveillance period. All subjects free from dementia, stroke, clinically diagnosed cardiovascular disease up to time testing. Statistical models adjusted for age, education, occupation, cigarette smoking, alcohol consumption, total cholesterol, diagnosis type II diabetes. Body mass index status (nonobese obese) blood pressure (normotensive hypertensive) then related performance (learning, memory, executive functioning, abstract reasoning) tests administered 4–6 y later. RESULTS: Adverse observed men only. Obese hypertensive performed more poorly than as either obese hypertensive, best was in nonobese, normotensive men. CONCLUSIONS: The adverse are cumulative with respect deficit.